Description
Application:Antitumor,Endocrine Therapy,Estrogen Synthesis Inhibitor,Inhibiting Estrogen Synthesis
A highly selective non-steroidal inhibitor of aromatase, the enzyme by which androstenedione is converted in peripheral tissues in postmenopausal women into estrone and further into estradiol. Reducing circulating estradiol levels in breast cancer patients has a therapeutic effect. In postmenopausal women Arimidex® in daily dose of 1 mg causes reduction of estradiol level by 80%.
Arimidex® has no progestagenic, androgenic and estrogenic activity.
Arimidex® in daily doses up to 10 mg has no effect on cortisol and aldosterone secretion, therefore, substitution of corticosteroids is not required when using Arimidex®.
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