Description
Anastrozole is occasionally used to supplement low testosterone. This drug works by decreasing the amount of estrogen the body makes.
It was originally developed to treat what’s called hormone receptor-positive breast cancer in postmenopausal women. Hormone receptor-positive means that the cancer cells grow in response to the hormone estrogen, which explains why anastrozole can treat these kinds of breast cancers.
Estradiol is made directly by the testicles, but the majority comes from the conversion of testosterone into estradiol by the aromatase enzyme. Anastrozole blocks the action of aromatase (called aromatization), which slows down the conversion of testosterone to estradiol. This boosts overall testosterone levels and lowers estradiol.
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